7-oxo-DHEA, 7alpha-OH-DHEA, and 7beta-OH-DHEA all also increase the liver content of the thermogenic enzymes mitochondrial sn-glycerol-3-phosphate dehydrogenase and cytosolic malic enzyme, and all to a greater extent than DHEA .

7-oxo-DHEA is about 2.5 times as potent as DHEA in inducing these enzymes .


Another possible mechanism by which 7-oxo-DHEA leads to fat loss is induction of peroxisome proliferator-activated receptors (PPARs). Specifically, DHEA is a preferential PPAR-alpha ligand, and 7-oxo-DHEA and the 7-OH metabolites have a greater affinity than DHEA. This can have a wide variety of effects, including increased mitochondrial uncoupling, regulation of genes that play a role in lipid metabolism, and increased levels of L-carnitine levels in various tissues . In summary, this effect will have a number of downstream effects that will each increase fat loss in their own right. The extent of PPAR-alpha activation from 7-oxo-DHEA supplementation in vivo is not known, and DHEA requires relatively high doses to have this effect .


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